Phosphorylation regulates human oct4

Author: kmie

August undefined, 2024

WebFunctional analysis of two sites, T234 and S235, suggested that phosphorylation within the homeobox region of OCT4 negatively regulates its activity by interrupting sequence … WebApr 2, 2012 · OCT4 is phosphorylated on serine 12 in ESCs Phosphorylation of OCT4 by kinases provides a potential mechanism to regulate OCT4 activity through signaling …

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WebPhosphorylation of T234 and S235 on OCT4 Regulates DNA Binding. Phosphorylation sites on OCT4 were scattered throughout the protein (Fig. 1A); however, two sites (T234 and … WebFIGURE 4 OCT4A Ser-111 phosphorylation regulates OCT4A subcellular localization. A, NTera2 cells were serum-starved and then treated with FGF2 (100 ng/ml) for 30 min in the … chs physician partners ny

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WebDec 11, 2015 · For instance, the level of OCT4, also known as POU5F1, is crucial for cell fate transitions and embryonic development.12,13If OCT4 protein is elevated more than 2-fold compared to normal conditions, stem cells loose their pluripotency and start differentiation into endoderm and mesoderm.14Moreover, a moderate increase of OCT4 is sufficient to … WebJan 1, 2024 · These PTMs play essential roles in regulating the structure, activity, and localization of the OCT4 protein and its interactions with other cellular components. The … WebPhosphorylation regulates human OCT4 Author: Brumbaugh, Justin, Hou, Zhonggang, Russell, Jason D., Howden, Sara E., Yu, Pengzhi, Ledvina, Aaron R., Coon, Joshua J., … description of paddington bear

Inaugural Article: Phosphorylation regulates human OCT4

WebApr 14, 2024 · Breast cancer represents the most common malignancy in women, with an increased incidence [1, 2].In 2024, 2.3 million people were estimated to be diagnosed with breast cancer worldwide, and 685,000 people died of this tumor [].Breast cancer is classified by the gene expression profiles into intrinsic subtypes, such as luminal A, luminal B, HER2 … WebPhosphorylation regulates human OCT4. Proc Natl Acad Sci U S A. 2012; 109(19):7162-8 (ISSN: 1091-6490) ... T234 and S235, suggested that phosphorylation within the homeobox region of OCT4 negatively regulates its activity by interrupting sequence-specific DNA binding. Mutating T234 and S235 to mimic constitutive phosphorylation at these sites ... chs physician assistant jobsWebNov 16, 2024 · Therefore, we hypothesized that OCT4 activity might be regulated by PTMs, especially phosphorylation. To identify the potential kinases of OCT4, we conducted a … description of papaya fruit

"WebNov 2, 2012 · Recent analysis of the human ES cell phosphoproteome indicates that OCT4 is phosphorylated ( 6 ), but the functional consequences of these modifications have not been determined. In addition, limited data are available on the mechanisms regulating the nuclear entry of OCT4 and how its nuclear localization is linked to signaling pathways. " - Phosphorylation regulates human oct4

Phosphorylation regulates human oct4

Serine 111 Phosphorylation Regulates OCT4A Protein Subcellular ...

WebApr 2, 2012 · We conclude that phosphorylation of T234 and S235 regulates OCT4 transcription primarily by altering its DNA binding capacity. Reprogramming experiments using the T234E_S235E and T234A_S235A mutants provided a perspective on the …

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WebJan 1, 2024 · OCT4 (also known as Oct3 and Oct3/4), which is encoded by Pou5f1, is expressed in early embryonic cells and plays an important role in early development, … WebAdditionally, phosphorylation of human OCT4 at Ser-229 by protein kinase A might partially regulate OCT4 transactivation activity (13). OCT4 is also a target for SUMO1 (small ubiquitin-related modifier 1) modification that occurs at a …

WebOct 5, 2024 · Phosphorylation of threonine 343 mediates global OCT4-phosphorylation (phos-OCT4 T343) • Phos-OCT4 T343 is crucial for OCT4 to protect embryonic stem cell pluripotency • Phos-OCT4 T343 binds to SOX2 but non-phos-OCT4 T343 binds to SOX17 in cell fate decision • Phos-OCT4 T343 may regulate lineage commitment in early embryonic … WebApr 2, 2012 · We conclude that phosphorylation of T234 and S235 regulates OCT4 transcription primarily by altering its DNA binding capacity. Reprogramming experiments …

WebPhosphorylation of Human Estrogen Receptor a by Protein Kinase A Regulates Dimerization DONGSHENG CHEN, PAUL E. PACE, ... (LBDs) and regulate transcription by binding to cis-acting enhancer elements in promoters of responsive genes as monomers or as homo- or heterodimers (12, 13, 55, 56, 83). Comparison of the amino acid sequences of WebSep 28, 2012 · Finally, we identified several signaling pathways which may mediate this phosphorylation and act in combination to regulate Oct4 transcriptional activity and …

WebSep 5, 2014 · Critical amounts of human Oct4-IA are required to sustain stem cell self-renewal and it has been shown that Oct4-IB is not related to stemness. In humans, Oct4 …

WebDec 12, 2024 · Our data thus suggest that phosphorylation of serine 347 regulates OCT4 protein stability and proteasomal degradation in mouse ESCs. Results OCT4 Is a Substrate of JNK1 and JNK2 Recent studies indicated that PTMs regulate the function of transcription factors, including Sox2, Klf4, and Oct4 ( Cai et al., 2012). description of paranoid schizophreniaWebPhosphorylation of T234 and S235 on OCT4 Regulates DNA Binding. Phosphorylation sites on OCT4 were scattered throughout the protein (Fig. L4); however, two sites (T234 and … description of paul in the bibleWebTherefore, phosphorylation of threonine343 is crucial for OCT4 function in the protection of ESC pluripotency. T343A ESCs Tend to Differentiate to Endoderm and Mesoderm Rather than to Ectoderm... description of pediatric psychiatric nurseWebJan 29, 2014 · MG132, a proteasome inhibitor, blocked LY294002-induced Oct4 reduction, indicating that Oct4 protein level is regulated by PI3K/Akt signaling via proteasome-dependent mechanism. Furthermore, analysis of Oct4 protein sequence revealed that it contained a consensus Akt phosphorylation motif. description of pearl harborWebthat OCT4 activity might be regulated by post-translational modifications, specifically phosphorylation. OCT4A sequence analysis conducted with the database PhosphoMotif … description of peeta mellarkWebAdditionally, phosphorylation of human OCT4 at Ser-229 by protein kinase A might partially regulate OCT4 transactivation activity (13. Saxe J.P. Tomilin A. Schöler H.R. Plath K. ... FIGURE 4 OCT4A Ser-111 phosphorylation regulates OCT4A subcellular localization. A, NTera2 cells were serum-starved and then treated with FGF2 (100 ng/ml) ... description of people in basketball court gymWebPhosphorylation regulates human OCT4. Brumbaugh J, Hou Z, Russell JD, Howden SE, Yu P, Ledvina AR, Coon JJ, Thomson JA Proc Natl Acad Sci U S A. 2012 May 8;109(19):7162-8. chs physician partners p.c